The classic symptoms of coeliac disease include pale, loose, and greasy stool (steatorrhoea) and weight loss or failure to gain weight. source
The classic symptoms of coeliac disease include pale, loose, and greasy stool (steatorrhoea) and weight loss or failure to gain weight.
The diarrhoea that is characteristic of coeliac disease is (chronic) pale, of large volume, and abnormally bad smelling. source
The diarrhoea that is characteristic of coeliac disease is (chronic) pale, of large volume, and abnormally bad smelling.
Coeliac disease has been linked with a number of conditions. source
Coeliac disease has been linked with a number of conditions.
IgA deficiency is present in 2.3% of people with coeliac disease, and in turn this condition features a tenfold increased risk of coeliac disease. source
IgA deficiency is present in 2.3% of people with coeliac disease, and in turn this condition features a tenfold increased risk of coeliac disease.
Pregnancy complications can occur in case of coeliac disease as an intercurrent disease in pregnancy. source
Pregnancy complications can occur in case of coeliac disease as an intercurrent disease in pregnancy.
Coeliac disease is caused by a reaction to gliadin, a prolamin (gluten protein) found in wheat. source
Coeliac disease is caused by a reaction to gliadin, a prolamin (gluten protein) found in wheat.
A small number of people with coeliac also react to oats. source
A small number of people with coeliac also react to oats.
There are various theories as to what determines whether a genetically susceptible individual will go on to develop coeliac disease. source
There are various theories as to what determines whether a genetically susceptible individual will go on to develop coeliac disease.
Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele. source
Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele.
About 20–30% of people without coeliac disease have also inherited either of these alleles. source
About 20–30% of people without coeliac disease have also inherited either of these alleles.
Around 5% of those people who do develop coeliac disease do not have typical HLA-DQ2 or HLA-DQ8 alleles (see below). source
Around 5% of those people who do develop coeliac disease do not have typical HLA-DQ2 or HLA-DQ8 alleles (see below).
The vast majority of people with coeliac have one of two types of the HLA-DQ protein. source
The vast majority of people with coeliac have one of two types of the HLA-DQ protein.
The majority of the proteins in food responsible for the immune reaction in coeliac disease are the prolamins. source
The majority of the proteins in food responsible for the immune reaction in coeliac disease are the prolamins.
The response to the 33mer occurs in most coeliacs who have a DQ2 isoform. source
The response to the 33mer occurs in most coeliacs who have a DQ2 isoform.
Other intestinal disorders may have biopsy that look like coeliac disease including lesions caused by Candida. source
Other intestinal disorders may have biopsy that look like coeliac disease including lesions caused by Candida.
