Creatine is a nitrogenous organic acid that occurs naturally in vertebrates. source
Creatine is a nitrogenous organic acid that occurs naturally in vertebrates.
Creatineis main role is to facilitate recycling of adenosine triphosphate (ATP), the energy currency of the cell, primarily in muscle and brain tissue. source
Creatineis main role is to facilitate recycling of adenosine triphosphate (ATP), the energy currency of the cell, primarily in muscle and brain tissue.
Creatine also acts as a pH buffer in tissues. source
Creatine also acts as a pH buffer in tissues.
Creatine synthesis primarily occurs in the liver and kidneys. source
Creatine synthesis primarily occurs in the liver and kidneys.
On average, Creatine is produced endogenously at an estimated rate of about 8.3 mmol or 1 gram per day in young adults. source
On average, Creatine is produced endogenously at an estimated rate of about 8.3 mmol or 1 gram per day in young adults.
Creatine is obtained through the diet at a rate of about 1 gram per day from an omnivorous diet. source
Creatine is obtained through the diet at a rate of about 1 gram per day from an omnivorous diet.
Creatine was identified in 1832 when Michel Eugène Chevreul isolated it from the basified water-extract of skeletal muscle. source
Creatine was identified in 1832 when Michel Eugène Chevreul isolated it from the basified water-extract of skeletal muscle.
In solution, creatine is in equilibrium with creatinine. source
In solution, creatine is in equilibrium with creatinine.
Creatine is a derivative of the guanidinium cation. source
Creatine is a derivative of the guanidinium cation.
Creatine is not an essential nutrient as it is naturally produced in the human body from the amino acids glycine and arginine. source
Creatine is not an essential nutrient as it is naturally produced in the human body from the amino acids glycine and arginine.
Synthesis primarily takes place in the kidney and liver, with creatine then being transported to the muscles via the blood. source
Synthesis primarily takes place in the kidney and liver, with creatine then being transported to the muscles via the blood.
Creatine supplements are used by athletes, bodybuilders, wrestlers, sprinters, and others who wish to gain muscle mass. source
Creatine supplements are used by athletes, bodybuilders, wrestlers, sprinters, and others who wish to gain muscle mass.
A meta analysis found that creatine treatment increased muscle strength in muscular dystrophies, and potentially improved functional performance. source
A meta analysis found that creatine treatment increased muscle strength in muscular dystrophies, and potentially improved functional performance.
Creatine treatment does not appear to improve muscle strength in people who have metabolic myopathies. source
Creatine treatment does not appear to improve muscle strength in people who have metabolic myopathies.
High doses of creatine leads to increased muscle pain and an impairment in activities of daily living when taken by people who have McArdle disease. source
High doses of creatine leads to increased muscle pain and an impairment in activities of daily living when taken by people who have McArdle disease.
When creatine is mixed with protein and sugar at high temperatures (above 148 °C), the resulting reaction produces heterocyclic amines (HCAs). source
When creatine is mixed with protein and sugar at high temperatures (above 148 °C), the resulting reaction produces heterocyclic amines (HCAs).