Amyloidosis is a rare and serious disease caused by accumulation of proteins in the form of abnormal, insoluble fibres. source
Amyloidosis is a rare and serious disease caused by accumulation of proteins in the form of abnormal, insoluble fibres.
The symptoms of amyloidosis are accordingly highly variable and confirmation of the presence of amyloid in the tissues can be challenging. source
The symptoms of amyloidosis are accordingly highly variable and confirmation of the presence of amyloid in the tissues can be challenging.
Amyloid fibrils are formed by aggregation (clumping) of normally soluble body proteins and accumulate progressively. source
Amyloid fibrils are formed by aggregation (clumping) of normally soluble body proteins and accumulate progressively.
forming amyloid deposits which disrupt the normal tissue architecture, damaging the function of tissues and organs and causing disease. source
forming amyloid deposits which disrupt the normal tissue architecture, damaging the function of tissues and organs and causing disease.
There are many different types of amyloidosis, each caused by formation of amyloid fibrils from different soluble precursor proteins in different patients. source
There are many different types of amyloidosis, each caused by formation of amyloid fibrils from different soluble precursor proteins in different patients.
About 30 different proteins are known to form amyloid fibrils in humans. source
About 30 different proteins are known to form amyloid fibrils in humans.
Amyloidosis is named and classified according to the identity of the respective fibril protein. source
Amyloidosis is named and classified according to the identity of the respective fibril protein.
The presentation of amyloidosis is broad and depends on the site of amyloid accumulation. source
The presentation of amyloidosis is broad and depends on the site of amyloid accumulation.
Amyloid deposition in the kidneys can cause nephrotic syndrome. source
Amyloid deposition in the kidneys can cause nephrotic syndrome.
In AA amyloidosis the kidneys are involved in 91–96% of people. source
In AA amyloidosis the kidneys are involved in 91–96% of people.
Amyloid deposition in the heart can cause both diastolic and systolic heart failure. source
Amyloid deposition in the heart can cause both diastolic and systolic heart failure.
People with amyloidosis do not get central nervous system involvement but can develop sensory and autonomic neuropathies. source
People with amyloidosis do not get central nervous system involvement but can develop sensory and autonomic neuropathies.
"Amyloid deposits occur in the pancreas of patients with diabetes mellitus, although it is not known if this is functionally important. source
"Amyloid deposits occur in the pancreas of patients with diabetes mellitus, although it is not known if this is functionally important.
The major component of pancreatic amyloid is a 37-amino acid residue peptide known as islet amyloid polypeptide or amylin. source
The major component of pancreatic amyloid is a 37-amino acid residue peptide known as islet amyloid polypeptide or amylin.
Diagnosis of amyloidosis requires tissue biopsy. Biopsy is assessed for evidence of characteristic amyloid deposits. source
Diagnosis of amyloidosis requires tissue biopsy. Biopsy is assessed for evidence of characteristic amyloid deposits.
Treatment depends on the type of amyloidosis that is present. source
Treatment depends on the type of amyloidosis that is present.
